G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/564 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2730042
The invention relates to diagnosing the presence or absence of antibodies, such as IgM, IgG or IgA antibodies, related to increased or decreased risk of developing Alzheimer's disease, using a phosphorylcholine conjugate. In addition, the invention relates to methods of immunization and prophylaxis, prevention and/or treatment of a subject against Alzheimer's disease, the method comprising the step of administering to the subject a pharmaceutical composition comprising at least one phosphorylcholine conjugate, or the step of administering to the subject an antibody preparation, for example a monoclonal antibody, with reactivity to a phosphorylcholine and/or a conjugate thereof.
La présente invention concerne la détermination de la présence ou de l'absence d'anticorps, tels que les anticorps IgM, IgG ou IgA, en relation avec un risque accru ou, au contraire minoré, d'être atteint de la maladie d'Alzheimer, et ce en utilisant un conjugué de phosphorylcholine. En outre, l'invention concerne des procédés d'immunisation et de prophylaxie, de prévention et/ou de traitement d'un sujet contre la maladie d'Alzheimer, ledit procédé comprenant l'étape consistant à administrer au sujet une composition pharmaceutique comprenant au moins un conjugué de phosphorylcholine, ou l'étape consistant à administrer au sujet une préparation d'anticorps, par exemple à base d'un anticorps monoclonal réagissant à une phosphorylcholine et/ou à un conjugué de celle-ci.
de Faire Ulf
Frostegard Johan
Pedersen Nancy
Athera Biotechnologies Ab
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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