New treatment of autoimmune conditions

G - Physics – 01 – N

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G01N 33/68 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2706849

The invention relates to methods and materials involved in diagnosing and treating autoimmune conditions. In par-ticular, the invention relates to methods and materials involved in identifying agent suitable for the prophylaxis, prevention and/or treatment of an autoimmune condition. The invention further relates to methods and materials involved in diagnosing autoimmune diseases like arthritis, multiple sclerosis and inflammatory bowels disease accompanied by decreased cellular uptake of amino acids caused by defects in cellular amino acid transporters like S1c38A1 (Solute carrier family 38, member 1). The invention also relates to methods and materials involved in diagnosing, treating, preventing, or delaying the onset and ameliorating the symptoms of au-toimmune conditions that are accompanied by defects in cellular amino acid transporters.

La présente invention concerne des procédés et des matériaux permettant le diagnostic et le traitement de conditions auto-immunes. En particulier, l'invention concerne des procédés et des matériaux permettant l'identification d'agent apte à la prophylaxie, la prévention et/ou le traitement d'une condition auto-immune. L'invention concerne également des procédés et des matériaux permettant le diagnostic de maladies auto-immunes telles que l'arthrite, la sclérose en plaques et l'affection abdominale inflammatoire accompagnées par le captage cellulaire réduit d'acides aminés provoqué par des défauts de transporteurs d'acides aminés tels que Slc38Al (famille 38 de transporteurs de solutés, membre 1). L'invention concerne en outre des procédés et des matériaux permettant le diagnostic, le traitement, la prévention, ou le retardement de l'apparition et l'amélioration de symptômes de conditions auto-immunes qui sont accompagnées de défauts de transporteur cellulaires d'acides aminés.

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