New tricyclic angiotensin ii agonists

Details New tricyclic angiotensin ii agonists New tricyclic angiotensin ii agonists

C - Chemistry, Metallurgy

07

D

C07D 409/10 (2006.01) A61K 31/4178 (2006.01) A61P 1/00 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2604797

There is provided compounds of Formula (I), wherein A, X1, X2, X3, X4, Y1, Y2, Y3, Y4, Z1, Z2, R4 and R5 have meanings given in the description, and pharmaceuticalfy-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.

La présente invention concerne des composés de Formule (I), où A, X1, X2, X3, X4, Y1, Y2, Y3, Y4, Z1, Z2, R4 et R5 ont les valeurs données dans la description, ainsi que des sels de qualité pharmaceutique desdits composés, lesdits composés pouvant être employés en tant qu'agonistes sélectifs du récepteur de l'AT2, et ainsi, en particulier, dans le traitement d'états pathologiques entre autres gastro-intestinaux, tels que la dyspepsie, du syndrome du côlon irritable (IBS) et du syndrome d'insuffisance multi-organes (MOF), ainsi que de troubles cardio-vasculaires.

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