New tricyclic angiotensin ii agonists

Details New tricyclic angiotensin ii agonists New tricyclic angiotensin ii agonists

C - Chemistry, Metallurgy

07

D

C07D 409/10 (2006.01) A61K 31/4025 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2604038

There is provided compounds of formula (I) wherein the dotted line, X1, X2, X3, A, Y1, Y2, Y3, Y4, Z1, Z2, R2 and R3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.

On procure des composés de formule (I) dans laquelle la ligne pointillée, X1, X2, X3, A, Y1, Y2, Y3, Y4, Z1, Z2, R2 et R3 ont les significations données dans la description, et leurs sels acceptables sur le plan pharmaceutique, lesquels composés sont utiles comme agonistes sélectifs du récepteur AT2, et par conséquent, en particulier, dans le traitement des conditions gastro-intestinales notamment, telles que la dyspepsie, l~IBS et le MOF, et des troubles cardiovasculaires.

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