New tricyclic thiazolo and thiazino derivatives and...

Details New tricyclic thiazolo and thiazino derivatives and... New tricyclic thiazolo and thiazino derivatives and...

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 513/14 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2134200

- 33 - Abstract The present invention concerns tricyclic thiazolo and thiazino derivatives of formula I (I) Image in which A represents a carbocyclic or heterocyclic ring, X can be an oxygen or sulphur atom or the group =NH, =N-C1-C6-alkyl or =S(O)2, R denotes an aliphatic residue with 1-9 C atoms which can be substituted by phenyl or a carbocyclic ring with 7-15 C atoms or a heterocyclic ring system, R1 denotes a hydrogen atom, an aliphatic residue with 1-6 C atoms or C1-C6 alkoxy, C1-C6 alkylmercapto, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, amino, C1- C6 alkylamino, di-C1-C6-alkylamino, sulfonamido, C1- C6 alkoxycarbonyl, carboxy, halogen, hydroxy, nitro, cyano, azido, phenyl or benzyloxy, - 34 - R2, R3, R4 and R5 can denote hydrogen, C1-C6 alkyl, C1- C6 hydroxyalkyl, cyano, carboxy or C1-C6 alkoxy- carbonyl or R2 and R4 can denote a further bond between the C atoms to which they are bound, R6 denotes hydrogen or C1-C6 alkyl, n denotes 0, 1 or 2 and m denotes 0 or 1 as well as tautomers, enantiomers, diastereomers and physiologically tolerated salts thereof. The invention in addition concerns pharmaceutical agents that contain compounds of formula I in particular for the treatment of viral infections.

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