C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 271/56 (2006.01) A23K 1/16 (2006.01) A61K 31/325 (2006.01) A61K 31/40 (2006.01) A61K 31/4453 (2006.01) A61P 3/06 (2006.01) A61P 13/04 (2006.01) A61P 31/10 (2006.01) C07C 271/24 (2006.01) C07C 333/06 (2006.01) C07D 207/14 (2006.01) C07D 211/14 (2006.01)
Patent
CA 2310055
The present invention relates to urethanes and the thio and dithio analogues thereof of general formula (see formula I) wherein m, n, A, X, Y and R1 to R8 are defined as in claim 1, the enantiomers, diastereomers and the salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
La présente invention concerne des uréthanes, ainsi que leurs analogues thio et dithio, correspondant à la formule générale (I), dans laquelle m, n, A, X, Y et les groupes R<1> à R<8> correspondent à la définition donnée dans la revendication 1, leurs énantiomères, leurs diastéréomères et leurs sels, en particulier, leurs sels d'addition d'acide physiologiquement compatibles, qui présentent de précieuses caractéristiques, en particulier, un effet inhibiteur vis-à-vis de la biosynthèse du cholestérol. L'invention concerne également des médicaments contenant ces composés, leur utilisation et leur procédé de production.
Adelgoss Gebhard
Eisele Bernhard
Hurnaus Rudolf
Maier Roland
Mark Michael
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Boehringer Ingelheim Pharma Kg
Fetherstonhaugh & Co.
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