New use

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/592 (2006.01) A61K 31/593 (2006.01) A61P 17/02 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2581693

The present invention relates to the use of a vitamin D compound active in up- regulating the expression and production of hCAP18 in humans for the manufacture of a medicament for treatment of conditions deficient in or benefiting from LL-37. The vitamin D active compound can be used as a medicament for treatment of injured tissues, chronic ulcers, burn wounds, skin infections and atopic dermatitis and for improving the microvasculature. UVB irradiation can also be used to up-regulate hCAP18.

La présente invention concerne l'utilisation d'un composé vitamine D actif dans la régulation positive de l'expression et dans la production de hCAP18 chez des personnes, pour la fabrication d'un médicament destiné au traitement d'états déficients en LL-37 ou bénéficiant de LL-37. Ce composé actif de vitamine D peut être utilisé comme médicament pour le traitement de tissus endommagés, des ulcères chroniques, des brûlures, des affections cutanées et des dermatoses atopiques et pour améliorer l'appareil microvasculaire. Une irradiation aux UVB peut aussi être utilisée pour la régulation positive de hCAP18.

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