New use of a pyridazinone derivative

Details New use of a pyridazinone derivative New use of a pyridazinone derivative

A - Human Necessities

61

K

A61K 31/50 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01)

Patent

CA 2334910

A method for the treatment of neurohumoral imbalance caused by alterations of cardiac function to prevent the development of heart failure or a method of increasing calcium sensitivity of contractile proteins of cardiac muscle comprises administering an effective amount of (R)-N-[4-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)phenyl]acetamide to a mammal in need of such treatment.

L'invention porte sur un procédé de traitement d'un déséquilibre neurohumoral provoqué par des modifications de la fonction cardiaque, ce procédé visant à empêcher la constitution d'une insuffisance cardiaque. L'invention porte également sur un procédé visant à accroître la sensibilité au calcium des protéines contractiles du muscle cardiaque et consistant à administrer à un mammifère nécessitant ce traitement une quantité efficace de (R)-N-[4-(1,4,5,6-tétrahydro-6-oxo-3-pyridazinyl)phényl]acétamide.

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