New use of adenovirus and nucleic acids coding therefor

Details New use of adenovirus and nucleic acids coding therefor New use of adenovirus and nucleic acids coding therefor

A - Human Necessities

61

K

A61K 48/00 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2546178

The invention relates to the use of a virus, preferably an adenovirus for producing a medicament, said virus being replication deficient in cells that do not contain YB-1 in the nucleus. The virus codes for an oncogen or oncogen product, in particular an oncogen protein, which transactivates at least one viral gene, preferably an adenoviral gene, said gene being selected from the group containing E1B55kDa, E4orf6, E4orf3 and E3ADP.

L'invention concerne l'utilisation d'un virus, de préférence un adénovirus, pour produire un médicament. Ce virus, à réplication déficiente dans des cellules qui n'ont pas YB-1 dans le noyau, code pour un oncogène ou pour un produit oncogène, notamment une protéine oncogène, lesquels transactivent au moins un gène viral, de préférence un gène adénoviral, ce gène étant sélectionné dans le groupe constitué par E1B55kDa, E4orf6, E4orf3 et E3ADP.

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