New use of dipeptidyl peptidase iv inhibitors

Details New use of dipeptidyl peptidase iv inhibitors New use of dipeptidyl peptidase iv inhibitors

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/04 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61P 25/00 (2006.01) A61P 25/06 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) C07D 207/04 (2006.01) C07D 277/04 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2424645

The present invention provides a new use of DPIV-inhibitors. The compounds of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, are useful in treating conditions mediated by DPIV or DPIV-Iike enzymes, such as immune, autoimmune or central nervous system disorder selected from the group consisting of strokes, tumors, ischemia, Parkinson's disease and migraines. In a more preferred embodiment, the compounds of the present invention are useful for the treatment of multiple sclerosis.

L'invention concerne une nouvelle utilisation d'inhibiteurs de la dipeptidyl peptidase IV. Les composés de l'invention et leurs formes de sel d'addition d'acide correspondants, acceptables au plan pharmaceutique, sont utiles dans le traitement d'états médiés par des enzymes du types DPIV ou DPIV, états tels que des troubles de l'immunité, auto-immuns ou du système nerveux central, faisant partie du groupe constitué des attaques, des tumeurs, de l'ischémie, de la maladie de Parkinson et des migraines. Dans un mode de réalisation idéal, les composés de l'invention sont utiles pour le traitement de la sclérose en plaques.

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