A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/194 (2006.01) A61K 31/198 (2006.01) A61P 9/14 (2006.01)
Patent
CA 2691746
The present invention relates to the new use of alpha-ketoglutarate, amides, and salts and mixtures thereof for the manufacture of a pharmaceutical preparation or a food or feed supplement for the in vivo therapeutic improvement of blood vessel elasticity, in particular arterial elasticity in a subject in need thereof. Improving the blood vessel elasticity may be used in the for the treatment and/or prophylaxis of hypertension, pulmonary arterial hypertension, cardiovascular disease, retinal vascular disease, heart failure, atherosclerosis, ventricular hypertrophy, stroke, arterial aneurysm, kidney failure, nephrosclerosis and diseases related to hypertension.
La présente invention concerne la nouvelle utilisation de l'alpha-cétoglutarate, d'amides, et de leurs sels et mélanges dans la fabrication d'une préparation pharmaceutique ou d'un aliment ou d'un complément nutritionnel pour l'amélioration thérapeutique in vivo de l'élasticité vasculaire, en particulier, l'élasticité artérielle chez un sujet en ayant besoin. L'amélioration de l'élasticité vasculaire peut être utilisée pour traiter et/ou prévenir l'hypertension, l'hypertension artérielle pulmonaire, les maladies cardiovasculaires, les maladies rétiniennes d'origine vasculaire, l'insuffisance cardiaque, l'athérosclérose, l'hypertrophie ventriculaire, l'attaque, l'anévrisme artériel, l'insuffisance rénale, la néphrosclérose et autres maladies associées à l'hypertension.
Borden Ladner Gervais Llp
Entress Ab
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