New use of nitrites and nitrates and compositions containing...

A - Human Necessities – 61 – K

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A61K 33/00 (2006.01) A61K 35/74 (2006.01) A61K 36/185 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2678097

Inorganic anions nitrate and nitrite influence metabolic rate and glucose homeostasis. Infusion of nitrite iv caused an acute drop in resting energy expenditure (oxygen consumption) and nitrate, when given perorally, caused a drop in oxygen consumption during exercise and a depression of the increase in blood glucose observed after an oral glucose tolerance test. The doses of nitrate and nitrite did not cause any detectable change in methemoglobin levels of blood. Also, nitrate and nitrite did not alter lactate levels in blood. This discovery provides useful treatments to regulate the energy expenditure and glucose homeostasis of a mammal by administration of inorganic nitrite and/or nitrate.

La présente invention concerne les anions inorganiques nitrate et nitrite qui influencent la vitesse métabolique et l'homéostase du glucose. La perfusion de nitrites par i.v. a provoqué une chute aiguë de la dépense énergétique de repos (consommation d'oxygène) et des nitrates, lorsqu'ils sont administrés per os, ont provoqué une chute de la consommation d'oxygène au cours d'exercice et une dépression de l'augmentation de la glycémie observée après un test oral de tolérance au glucose. Les doses de nitrates et de nitrites n'ont provoqué aucune variation détectable des taux de méthémoglobine dans le sang. En outre, les nitrates et les nitrites n'ont pas modifié les taux de lactates dans le sang. Cette découverture procure des traitements utiles pour réguler la dépense énergétique et l'homéostase du glucose d'un mammifère par l'administration de nitrites et/ou de nitrates inorganiques.

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