New use of peptide derivative

Details New use of peptide derivative New use of peptide derivative

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61K 38/04 (2006.01)

Patent

CA 2058168

ABSTRACT An antiinflammatory or gastrointestinal motility-modulating composition comprising a peptide derivative of the general formula : Image wherein R1 is hydrogen or an acyl group; R2 is hydroxy and R3 is carboxy or protected carboxy, or R2 and R3 are linked together to represent a group of the formula : Image ; R4 is hydroxy or protected hydroxy; R5 is hydroxy or protected hydroxy; R6 is hydroxy, protected hydroxy or lower alkoxy; and ??? is a single bond or a double bond, or a pharmaceutically acceptable salt thereof as an active ingredient, in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient. The use of the above peptide derivative or salt for the manufacture of a-medic- ament for preventing and/or treating inflammation or for modulating the gastrointestinal motility is also disclosed, as well as the above mentioned method of prevention and/or treatment.

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