New use of taxoid derivatives

Details New use of taxoid derivatives New use of taxoid derivatives

A - Human Necessities

61

K

A61K 31/335 (2006.01) A61K 31/337 (2006.01)

Patent

CA 2341191

The present invention relates a new use of taxoid derivatives. It relates more precisely to a method for treating abnormal cell proliferation of different resistant cell lines expressing multidrug resistance P-glycoprotein. This type of cells are representative of colon cancer cells. The products of the present invention are also usable to treat the colon cancer of mammals including men. The preferred compound is 4.alpha.-acetoxy-2.alpha.-benzoyloxy-5.beta., 20- epoxy-1.beta.-hydroxy-7.beta.-dimethoxy-9-oxo-11-taxen-13.alpha.-yl (2R,3S)-3- tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate.

L'invention concerne une nouvelle utilisation de dérivés taxoïdes et plus précisément une méthode de traitement de la prolifération cellulaire anormale de différentes lignées cellulaires exprimant de la P-glycoprotéine résistant à l'action de plusieurs médicaments. Ce type de cellules est représentatif des cellules du cancer du côlon. Les produits de l'invention peuvent également être utilisés pour le traitement du cancer du côlon chez les mammifères dont l'homme.

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