New uses of suppressive macrophage activation factors

Details New uses of suppressive macrophage activation factors New uses of suppressive macrophage activation factors

A - Human Necessities

61

K

A61K 38/19 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 19/00 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 15/19 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2390415

The present invention discloses new, specific uses of polypeptides denominated as suppressive macrophage activation factors (SMAF's). More specifically, the present invention discloses that SMAF-1 and/or SMAF-2 modulate the production of Th1, Th2 and/or Th3 cytokines and indicates how the latter molecules, nucleic acids encoding them and antibodies against them can be used to treat diseases mediated by type 1, type 2 and/or type 3 responses such as inflammation, infections, allergies, autoimmune diseases, transplant rejections, graft-versus-host disease, malignancies and diseases involving mucosal immunity.

La présente invention concerne de nouvelles utilisations spécifiques de polypeptides connus sous le nom de facteurs d'activation des macrophages suppresseurs (SMAF). Plus spécifiquement, l'invention concerne la modulation de la production de cytokines Th1, Th2 et/ou Th3 par SMAF-1 et/ou SMAF-2, indiquant comment ces molécules, les acides nucléiques codant pour celles-ci et les anticorps contre celles-ci peuvent être utilisés dans le traitement de maladies associées à des réponses de type 1, type 2 et/ou type 3 telles que l'inflammation, les infections, les allergies, les maladies auto-immunes, les rejets de greffes, la maladie du greffon contre l'hôte, les affections malignes et les maladies associées à l'immunité des muqueuses.

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