A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 35/56 (2006.01) A61P 35/00 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2374294
New vaccines for use as immunotherapeutic agents in the treatment of cancer, particularly but not limited to prostate cancer, are described. The invention relates to cell co-culture techniques which leads to a significant enhancement of the phenotype of cell lines, particularly allogeneic cell lines, towards a more in vivo phenotype resulting in a vaccine reflecting a more realist phenotypic representation of an in vivo tumour. Further, the invention relates to whole cell cancer vaccines having an immunogenic component which comprises co-cultured malignant and non-malignant cells. Such vaccines produced by the various co-culture techniques described have additional advantages over single cell suspension vaccines in the mode of presentation to the immune system which leads to enhanced performance in treating the disease.
L'invention concerne des nouveaux vaccins, utiles en tant qu'agents immunothérapiques dans le traitement du cancer et notamment, sans y être limité, dans le traitement du cancer de la prostate. L'invention concerne également des nouvelles techniques de co-culture de cellules, permettant d'agir de manière importante sur le phénotype des lignées cellulaires, notamment des lignées cellulaires allogéniques, pour obtenir un phénotype plus in vivo résultant en un vaccin représentant un phénotype plus réaliste d'une tumeur in vivo. En outre l'invention concerne des vaccins contre le cancer, à base de cellules entières, comprenant un composant immunogène comportant une co-culture de cellules malignes et non malignes. De tels vaccins produits à l'aide des diverses techniques décrites de co-cultures possèdent des avantages supplémentaires par rapport aux vaccins unicellulaires en suspension, dans le mode de présentation au système immun, ce qui contribue à l'obtention de performances accrues dans le traitement de la maladie.
Chana Haj
Smith Peter
Stevenson Darren
Sutton Andrew
Thraves Peter
Onyvax Limited
Sim & Mcburney
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