Newcastle disease virus administration

Details Newcastle disease virus administration Newcastle disease virus administration

A - Human Necessities

61

K

A61K 35/76 (2006.01) A61P 35/00 (2006.01) C12N 7/00 (2006.01) A61K 39/17 (2006.01)

Patent

CA 2519294

A mammalian subject having a tumor is treated by a method comprising administering an effective amount of a Newcastle disease virus, wherein the virus is administered to the subject in one or more cycles; and at least one cycle comprises administering sequentially one or more initial doses of from 1.8 X 1010 PFU to 4.8 X 1010 PFU of the virus per square meter of patient surface area followed by administering one or more subsequent doses of from 2.4 X 1010 PFU to 1.2 X 1011 PFU of the virus per square meter of patient surface area.

L'invention concerne un procédé permettant de traiter un sujet mammalien présentant une tumeur, par administration d'une dose efficace de virus de la maladie de Newcastle. Selon l'invention, ledit virus est administré au sujet en un ou plusieurs cycles. Au cours d'au moins un cycle, le procédé consiste à administrer séquentiellement une ou plusieurs doses initiales comprenant entre 1,8 X 10?10¿ PFU et 4,8 X 10?10¿ PFU de virus par mètre carré de la surface du patient, puis à administrer une ou plusieurs doses subséquentes comprenant entre 2,4 X 10?10¿ PFU et 1,2 X 10?11¿ PFU de virus par mètre carré de la surface du patient.

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