Nf-atp, a t lymphocyte dna-binding protein

Details Nf-atp, a t lymphocyte dna-binding protein Nf-atp, a t lymphocyte dna-binding protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/44 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2153967

An isolated NF-ATp protein, a T lymphocyte DNA binding protein, is described. Isolated nucleic acids encoding the protein are also disclosed, as are methods for producing the protein by recombinant means. Methods for screening potential immunosuppressant compounds, which interfere with or inhibit lymphokine gene activation through the NF-AT pathway, are described. Such methods detect phosphorylation of the NF-AT protein.

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