Nf-.kappa.b activation regulatory protein, i.kappa.b-beta

Details Nf-.kappa.b activation regulatory protein, i.kappa.b-beta Nf-.kappa.b activation regulatory protein, i.kappa.b-beta

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/02 (2006.01) C12Q 1/37 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2210441

The present invention provides a novel polypeptide, I.kappa.B-.beta., which binds to and effects NF-.kappa.B gene activation. Also provided is the nucleotide sequence encoding I.kappa.B-.beta. and methods of identifying compositions which affect I.kappa.B-.beta./NF-.kappa.B complexes. Methods of treatment of disorders associated with NF-.kappa.B induced gene activation are also described herein.

L'invention concerne un nouveau polypeptide, I kappa B- beta qui se lie à NF- kappa B et modifie son activation génique. L'invention porte également sur la séquence nucléotidique codant I kappa B- beta et sur des procédés d'identification de compositions modifiant les complexes I kappa B- beta /NF- kappa B. Elle se rapporte aussi à des méthodes de traitement de troubles associés à l'activation génique induite par NF- kappa B.

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