Nf-kb inhibitors containing as the active ingredient...

Details Nf-kb inhibitors containing as the active ingredient... Nf-kb inhibitors containing as the active ingredient...

C - Chemistry, Metallurgy

07

D

C07D 279/12 (2006.01) A61K 31/00 (2006.01) A61K 31/12 (2006.01) A61K 31/122 (2006.01) A61K 31/165 (2006.01) A61K 31/19 (2006.01) A61K 31/245 (2006.01) A61K 31/335 (2006.01) A61K 31/36 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07C 50/04 (2006.01) C07C 50/28 (2006.01) C07C 66/00 (2006.01) C07C 225/24 (2006.01) C07C 235/72 (2006.01) C07C 235/78 (2006.01) C07D 207/04 (2006.01) C07D 207/08 (2006

Patent

CA 2290630

NF-B inhibitors containing as the active ingredient benzoquinone derivatives represented by general formula (I), hydroquinone compounds thereof or salts of the same, wherein R1, R2 and R3 independently represent each H, C1-5 alkyl or C1-5 alkoxy; R4 represents H, hydroxy-methyl, alkyl or optionally esterified or amidated carboxy; Z is represented by formula (A); and n is from 0 to 6.

L'invention concerne des inhibiteurs de NF-?B contenant en tant qu'ingrédient actif des dérivés de benzoquinone représentés par la formule générale (I), des composés hydroquinone ou des sels de ces derniers, dans laquelle R¿1?, R¿2? et R¿3? représentent chacun indépendamment H, alkyle C¿1-5? ou alcoxy C¿1-5?; R¿4? représente H, hydroxyméthyle, alkyle ou du carboxy éventuellement estérifié ou amidé; Z est représenté par la formule (A); et n est un nombre de 0 à 6.

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