C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/38 (2006.01) A61K 31/00 (2006.01) C07C 233/55 (2006.01) C07C 271/30 (2006.01) C07C 271/58 (2006.01) C07C 275/42 (2006.01) C07C 311/08 (2006.01) C07C 311/13 (2006.01) C07D 211/00 (2006.01) C07D 215/16 (2006.01) C07D 217/12 (2006.01) C07D 217/22 (2006.01) C07D 231/56 (2006.01) C07D 239/84 (2006.01) C07D 257/04 (2006.01) C07D 261/20 (2006.01) C07D 277/82 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2586156
The present invention relates to niacin receptor agonists of formula: (I); as well as pharmaceutically acceptable salts and solvates. The compounds are useful for treating dyslipidemias, and in particular, reducing serum LDL, VLDL and triglycerides, and raising HDL levels. Pharmaceutical compositions and methods of treatment are also included.
La présente invention concerne des agonistes des récepteurs de niacine de formule I, ainsi que des sels et solvates pharmaceutiquement acceptables. Lesdits composés sont utiles pour le traitement des dyslipidémies, et en particulier, pour réduire les taux de LDL, de VLDL et de triglycérides sériques, et pour élever les taux de HDL. L'invention concerne également des compositions pharmaceutiques et des méthodes de traitement.
Beresis Richard T.
Chen Weichun
Colletti Steven L.
Deng Qiaolin
Ding Fa-Xiang
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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