Nicorandil-containing preparation for injection

A - Human Necessities – 61 – K

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A61K 9/14 (2006.01) A61K 9/19 (2006.01) A61K 31/455 (2006.01) A61K 47/12 (2006.01)

Patent

CA 1285485

NICORANDIL-CONTAINING PREPARATION FOR INJECTION Abstract of the Disclosure: A non-liquid type preparation for injection that has improved stability contains N-(2-hydroxyethyl)-nicotinamide nitrate ester (generally known as nicorandil) and an inorganic or organic acid and/or an alkaline metal salt thereof. These ingredients, together with an excipient that is pharmaceutically acceptable, may be dissolved in a solvent, sterilized by filtration and freeze-dried to obtain a freeze-dried preparation, or may be dissolved in a solvent under an aseptic condition and recrystallized to obtain an injectable powder. Nicorandil preparations according to the present invention are very stable and useful in clinical applications.

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