Nicotinamide derivatives

Details Nicotinamide derivatives Nicotinamide derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/82 (2006.01) A61K 31/44 (2006.01) C07D 213/64 (2006.01) C07D 213/643 (2006.01) C07D 213/75 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2285548

A compound of formula (I): (see formula I) wherein m, n, o, p, q, r are integers; A is O, NH or S; B is 0 or NH; D is O or NR9, wherein R9 is H or alkyl; E is CH2, 0, NH, or S(O)a, wherein a is 0, 1 or 2; R1 is H, optionally substituted alkyl or optionally substituted heterocycle; R2 and R3 may be taken together to form a carbonyl or cycloalkyl, or R2, R3 and R4 are independently H, OH, halo, CN, carboxy, nitro, or optionally substituted amino; R5 is a saturated or unsaturated cyclic or bicyclic (C3-C7) heterocyclic group; R6, R7 and R8 are each independently H, halo, carboxy, optionally substituted amino, nitro, hydroxy, optionally substituted alkyl, acyloxy, or heteroaryl, or R7 and R8 may be taken together to form a fused bicyclic ring, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, inflammatory and central nervous system disorders such as asthma, chronic obstructive pulmonary disease, adult respiratory diseases syndrome, shock, fibrosis, pulmonary hypersensitivity, allergic rhinitis, atopic dermatitis, psoriasis, weight control, rheumatoid arthritis, cachexia, Crohn's disease, ulcerative colitis, arthritic conditions and other inflammatory diseases, depression, multi-infarct dementia and AIDS.

La présente invention concerne un composé représenté par la formule (I) dans laquelle m, n, o, p, q, r, A, B, D, E, R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7> et R<8>, définis dans la description, sont utilisés dans le traitement d'affections respiratoires, allergiques, rhumatoïdes de la maîtrise du poids, et des désordres du système nerveux central, comme l'asthme, les maladies respiratoires obstructives chroniques, le syndrome de détresses respiratoire de l'adulte, les états de choc, les fibroses, l'hypersensibilité pulmonaire, la rhinite allergique, les dermites atopiques, le psoriasis, la maîtrise du poids, la polyarthrite rhumatoïde, la cachexie, la maladie de Crohn, la recto-colite hémorragique, les états arthritiques et autres maladies inflammatoires, la dépression, la démence athéroscléreuse et le sida.

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