Nicotinamide derivatives and their use as therapeutic agents

Details Nicotinamide derivatives and their use as therapeutic agents Nicotinamide derivatives and their use as therapeutic agents

A - Human Necessities

61

K

A61K 31/496 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01) C07D 401/00 (2006.01)

Patent

CA 2573198

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where m, n, p, V, R1, R2, R3, R4, R5 and R6 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

Il est exposé des procédés de traitement d'une maladie ou affection médiée par la SCD (Stéaroyl Coenzyme A désaturase) chez un mammifère, de préférence chez un humain, lesquels procédés comprennent d'administrer à un mammifère qui en a besoin un composé de formule (I) : où m, n, p, V, R1, R2, R3, R4, R5 et R6 sont définis ici. Il est également exposé des compositions pharmaceutiques comprenant les composés de formule (I).

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