Nicotinamide derivatives useful as pde4 inhibitors

Details Nicotinamide derivatives useful as pde4 inhibitors Nicotinamide derivatives useful as pde4 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/82 (2006.01) A61K 31/455 (2006.01) A61P 37/00 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2534262

This invention relates to nicotinamide derivatives of formula (I) and to pharmaceutical compositions containing, and the uses of such derivatives as PDE4 inhibitors wherein R7 is attached to the 3- or 4-position of the phenyl ring and is S(O)pR8, R8 is (C1-C4)alkyl optionally substituted by (C3- C6)cycloalkyl; m is 0 or 1; L is a (C3-C8)carbocyclic non-aromatic ring; and the remaining variables are as defined in the claims.

L'invention se rapporte à des dérivés de nicotinamide de la formule (I), à des compositions pharmaceutiques les contenant et à leurs utilisations comme inhibiteurs de PDE4; formule dans laquelle R¿7? est lié en position 3 ou 4 du cycle phényle et représente S(O)¿p?R¿8?, R¿8? représente (C¿1?-C¿4?)alkyle éventuellement substitué par (C¿3?-C¿6?)cycloalkyle; m vaut 0 ou 1; L représente un cycle non aromatique (C¿3?-C¿8?)carbocyclique; et les variables restants sont tels que définis dans les revendications.

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