Nicotinamide derivatives useful as pde4 inhibitors

Details Nicotinamide derivatives useful as pde4 inhibitors Nicotinamide derivatives useful as pde4 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/82 (2006.01) A61K 31/465 (2006.01) A61P 11/00 (2006.01) A61P 17/02 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2475712

The invention relates to nicotinamide derivatives of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are phosphodiesterase-4 inhibitors and are useful in numerous diseases, disorders and ( conditions, in particular inflammatory, allergic, respiratory diseases, disorders and conditions, as well as wounds.

L'invention concerne des dérivés de nicotinamide de la formule (1) et des procédés de préparation d'intermédiares utilisés dans la préparation de compositions contenant de tels dérivés, des procédés de préparation de ces compositions et les utilisations de tels dérivés. Les dérivés de nicotinamide selon la présente invention sont des inhibiteurs de la phosphodiestérase-4 et sont utiles dans de nombreux troubles, maladies et états, notamment dans les troubles, maladies et états inflammatoires, allergiques, respiratoires ainsi que pour les blessures.

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