Nicotinamide riboside and analogues thereof

Details Nicotinamide riboside and analogues thereof Nicotinamide riboside and analogues thereof

C - Chemistry, Metallurgy

07

H

C07H 19/048 (2006.01) A61K 31/706 (2006.01)

Patent

CA 2610854

Provided herein are sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

L'invention concerne des composés modulant la sirtuine et des procédés d'utilisation de ces derniers. Les composés modulant la sirtuine peuvent être utilisés pour augmenter la durée de vie d'une cellule, et pour traiter et/ou prévenir une grande variété de troubles et maladies parmi lesquels des troubles et maladies liés au vieillissement et au stress, au diabète, à l'obésité, les maladies neurodégénératives, les maladies cardiovasculaires, les troubles de la coagulation sanguine, l'inflammation, le cancer et/ou les bouffées congestives. L'invention porte également sur des compositions comprenant un composé modulant la sirtuine combiné à un autre agent thérapeutique.

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