Nicotine antagonists for nicotine-responsive...

A - Human Necessities – 61 – K

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A61K 31/5415 (2006.01) A61K 31/13 (2006.01) A61K 31/454 (2006.01) A61K 31/519 (2006.01) A61K 45/06 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2300148

Nicotine-responsive neuropsychiatric disorders can be treated by administering a nicotine antagonist, particularly mecamylamine. Combination therapy of mecamylamine with a neuroleptic drug also is disclosed. The neuropsychiatric disorders include Tourette's syndrome, schizophrenia, depression, bipolar disorder, tremors, attention deficit hyperactivity disorder, obsessive-compulsive disorder, hemidystonia, rage outbursts and tardive dyskinesia.

On peut traiter des troubles neuropsychiatriques sensibles à la nicotine en administrant un antagoniste de la nicotine, en particulier la mécamylamine. Un traitement associé de mécamylamine avec un médicament neuroleptique est aussi décrit. Les troubles neuropsychiatriques comprennent le syndrome de Tourette, la schizophrénie, la dépression, le trouble bipolaire, les tremblements, l'hyperactivité avec déficit de l'attention, la psychonévrose obsessionnelle, l'hémidystonie, les accès de fureur et les dyskinésies tardives.

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