A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/465 (2006.01) A61K 9/00 (2006.01) A61K 9/127 (2006.01) A61K 9/70 (2006.01)
Patent
CA 2304042
Polar lipid formulations of nicotine in liquid crystals and colloidal dispersions thereof and precursors or offspring thereof which when in contact with body fluid and/or by the influence of body temperature, are transformed to a liquid crystal or a mixture of liquid crystals, which functions as a controlled release matrix for nicotine suitable in e.g. smoking cessation and/or replacement therapies. Disclosed compositions of said liquid crystals or dispersions thereof, their precursors or offspring containing nicotine and anti-irritants or a local analgesic, or any combination of these reduce local irritation of nicotine and masks its taste. Applicable routes of administration and devices includes buccal, using chewing gum in which liquid crystals, dispersions thereof, or precursor or offspring thereof are formulated, buccal adhesives, gels and patches, using mucoadhesive liquid crystal, dispersions thereof or precursor thereof, and mouth spray using dispersion of said liquid crystals, their precursors or offspring, nasal spray and gel using said liquid crystals or their dispersions, their precursors or offspring, topical, using said liquid crystal or their precursors or offspring in adhesive patches and gels.
L'invention porte sur des préparations de nicotine sous forme de lipides polaires en cristaux liquides, sur leurs dispersions colloïdales sur leurs précurseurs et descendants qui, en contact avec les fluides corporels et/ou sous l'influence de la température du corps se transforment en un cristal liquide ou en un mélange de cristaux liquides jouant le rôle d'une matrice à libération contrôlée utilisable par exemple dans des thérapies de sevrage de fumeurs et/ou de remplacement. Les susdites préparations contiennent de la nicotine, des anti-irritants ou un analgésique local ou leur combinaison qui en réduisent l'irritation locale et en masquent le goût. L'administration peut se faire par voie buccale au moyen de chewing gum, d'adhésifs buccaux, de gels ou de timbres contenant les susdits ingrédients, de pulvérisations buccales, par pulvérisations ou gels nasaux, ou par applications topiques de timbres et de gels.
Andersson Sven Borje
Jonn Stefan
Landh Tomas
Gowling Lafleur Henderson Llp
Pharmacia & Upjohn Ab
Pharmacia Aktiebolag
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