Nicotine immunonanotherapeutics

A - Human Necessities – 61 – K

Patent

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A61K 39/00 (2006.01)

Patent

CA 2740248

The present invention pro-vides compositions and systems for delivery of nanocarriers to cells of the immune sys-tem. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an im-munofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention pro-vides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof. For example, the present invention describes nanocarriers ca-pable of eliciting an immune response and the production of anti-nicotine antibodies.

La présente invention concerne des compositions et des systèmes pour l'administration de nanoporteurs à des cellules du système immunitaire. L'invention concerne des nanoporteurs capables de stimuler une réponse immunitaire dans des lymphocytes T et/ou des lymphocytes B. L'invention concerne des nanoporteurs qui comprennent une surface immuno-active ayant une pluralité de groupes nicotine. La présente invention concerne en outre des procédés de conception, de fabrication et d'utilisation de nanoporteurs et des compositions pharmaceutiques de ceux-ci. Par exemple, la présente invention concerne des nanoporteurs capables de provoquer une réponse immunitaire et la production d'anticorps anti-nicotine.

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