Nicotinic acid compositions for treating hyperlipidemia and...

A - Human Necessities – 61 – K

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A61K 31/455 (2006.01) A61K 9/20 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2283159

An orally administered antihyperlipidemia composition according to the present invention includes from about 250 to about 3000 parts by weight of nicotinic acid, and from about 5 to about 50 parts by weight of hydroxypropyl methylcellulose. Also, a method of treating hyperlipidemia in a hyperlipidemic having a substantially periodic physiological loss of consciousness includes the steps of forming a composition having an effective antihyperlipidemic amount of nicotinic acid and a time release sustaining amount of a swelling agent. The method also includes the step of orally administering the composition to the hyperlipidemic once per day "nocturnally", that is in the evening or at night.

L'invention concerne une composition antihyperlipidémie, administrée par la voie orale, qui contient entre environ 250 à environ 3000 parts en poids d'acide nicotinique et entre environ 5 et 50 parts en poids d'hydroxypropylméthylcellulose. L'invention se rapporte également à un procédé permettant de traiter l'hyperlipidémie chez une personne qui en est atteinte et qui présente une perte de conscience physiologique sensiblement périodique. Ce procédé comporte les étapes de formation d'une composition contenant une quantité d'acide nicotinique suffisante pour lutter contre l'hyperlipidémie et une quantité d'agent de gonflement permettant une libération prolongée de la composition. Le procédé comporte également l'étape d'administration par la voie orale de la composition, à la personne souffrant d'hyperlipidémie, une fois par jour et de nuit, c'est à dire le soir ou pendant la nuit.

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