Nicotinic acid derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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260/245.65, 260/

C07D 401/00 (2006.01) C07D 251/18 (2006.01) C07D 401/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 1185972

Abstract of the Disclosure The present invention relates to novel nicotinoylbenzoguanamine derivatives represented by the following general formula (I) Image (I) and acid addition salts thereof. In the formula, X and Y are the same or different and stand for hydrogen or halogen (excluding the case where both X and Y are hydrogens) and Z stands for mono-(lower alkyl) amino, di-(lower alkyl) amino, piperidino, pyrrolidino, or morpholino. The compounds represented by the above general formula (I) strongly inhibit a reversed passive Arthus reaction.

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