C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/266
C07D 401/02 (2006.01) A61K 31/395 (2006.01) C07D 213/80 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01)
Patent
CA 2011144
The invention is concerned with novel compounds of the formula: Image wherein R1 is hydrogen or C1-C6 alkyl; Y is -CH2-, -O-, Image , Image or Image ; R2-NR2 is C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, phenyl which may be mono- or di-substituted on the phenyl ring with C1-C6 alkoxy, benzyl or phenylethyl which may be mono- or di-substituted on the aromatic ring with C1-C6 alkoxy, diphenylmethyl, carbo(C1-C2)alkoxy, or furanyl or pyrrolinidyl which is linked to the nitrogen atom via carbonyl or carbonylmethylene; m is 2 or 3; and n is 0 or 1, with the proviso that when Y is Image , R1 is hydrogen, m is 2 and n is 0, R2 is not methyl, and physiologically accpetable acid addition salts thereof. The compounds of formula (I) have a blood flow-increasing action and can be used for the therapy or prevention of diseases in the cardiovascular system.
Koyama Hiroyasu
Miura Katsutoshi
Sakurai Einosuke
Sugai Toshiji
Yamada Hiroaki
Koyama Hiroyasu
Miura Katsutoshi
Nisshin Flour Milling Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Sakurai Einosuke
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