Nicotinic receptor agonists for the treatment of...

A - Human Necessities – 61 – K

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A61K 31/495 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2441096

This invention relates to the use of nicotine receptor agonists analogues or derivatives thereof for treating pulmonary inflammatory diseases, including asthma, interstitial pulmonary fibrosis (IPF), sarcoidosis, hypersensitivity pneumonitis (HP), chronic HP and bronchiolitis obliterans with organizing pneumonitis (BOOP). Such agonists are expected to have fewer side effects than other anti-inflammatory drugs, such as steroids. Moreover, these agonists can be used alone or in combination with other anti- inflammatory drugs to alleviate pulmonary diseases.

La présente invention concerne l'utilisation d'agonistes de récepteurs nicotiniques pour le traitement d'affections inflammatoires, y-compris des affections pulmonaires. De tels agonistes s'avèrent entraîner moins d'effets secondaires que d'autres anti-inflammatoires tels que les stéroïdes. En outre, ces agonistes peuvent s'utiliser seuls ou en association avec d'autres anti-inflammatoires pour soulager des affections pulmonaires.

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