Nicotinyl aspartyl ketones as inhibitors of caspase-3

Details Nicotinyl aspartyl ketones as inhibitors of caspase-3 Nicotinyl aspartyl ketones as inhibitors of caspase-3

C - Chemistry, Metallurgy

07

D

C07D 213/82 (2006.01) A61K 31/44 (2006.01) A61P 9/10 (2006.01) C07D 401/12 (2006.01) C07D 405/04 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2386411

Caspase-3 inhibiting compounds of formula (I): as well as pharmaceutical compositions and methods of treatment are disclosed. The compounds are useful for treating caspase-3 mediated diseases and conditions, among which are cardiac or cerebral ischemia or reperfusion injury, type I diabetes, immune deficiency syndrome, includings AIDS, cerebral and spinal cord trauma injury, organ damage during transplantation, alopecia, aging, Parkinson's disease, Alzheimer's disease, Down's syndrome, spinal muscular atrophy, multiple sclerosis and neurodegenerative disorders.

L'invention concerne des composés inhibiteurs de la caspase-3 représentés par la formule générale (I), ainsi que des compositions pharmaceutiques et des méthodes de traitement. Lesdits composés sont utiles dans le traitement de maladies et d'états induits par la caspase-3, parmi lesquelles les ischémies cardiaques ou cérébrales ou les lésions dues à une reperfusion, le diabète type 1, le syndrome d'immunodéficience, y compris le SIDA, les lésions cérébrales et les traumatismes médullaires, les dommages subits par des organes lors d'une greffe, l'alopécie, le vieillissement, la maladie de Parkinson, la maladie d'Alzheimer, le syndrome de Down, la maladie d'Aran-Duchenne, la sclérose en plaques et les troubles neurodégénératifs.

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