Nima interacting proteins

Details Nima interacting proteins Nima interacting proteins

C - Chemistry, Metallurgy

12

N

C12N 15/61 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C12N 9/90 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/533 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2235225

A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA--induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or expression are also provided.

Nouvelle classe de protéines interagissant avec la NIMA (PIN), par exemple Pin1. Pin1 provoque une interruption de G2 et retarde la mitose provoquée par la NIMA lorsque celle-ci est surexprimée et déclenche l'arrêt de la mitose et la fragmentation de l'ADN lorsque la NIMA est épuisée. Des méthodes d'identification d'autres protéines Pin et des protéines interagissant avec les Pin et d'identification de compositions affectant l'activité ou l'expression des Pin sont également décrites.

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