Nimesulide gel systems for topical use

Details Nimesulide gel systems for topical use Nimesulide gel systems for topical use

A - Human Necessities

61

K

A61K 31/18 (2006.01) A61K 9/06 (2006.01) A61K 31/63 (2006.01) A61K 47/00 (2006.01) A61K 47/06 (2006.01) A61K 47/10 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2279277

The present invention relates to nimesulide topical formulations comprising a carboxyvinylpolymer neutralized as a gel-forming agent or a polyacrylamide- isoparaffin and a solvent selected from the group consisting of ethanol, isopropanol and diethylene glycol monoethyl ether, and to the process for the preparation thereof. Said formulations have advantages such as higher stability of the system and bioavailability of the active ingredient.

La présente invention concerne des formulations topiques de nimésulide. Ces formulations comprennent un carboxyvinylpolymère neutralisé sous forme d'agent gélifiant ou une isoparaffine de polyacrylamide et un solvant sélectionné dans le groupe se composant d'éthanol, d'isopropanol et d'éther de diéthylèneglycol et de monoéthyle. L'invention concerne aussi le procédé de préparation de ces produits. Ces formulations ont l'avantage de présenter une meilleure stabilité du système et une biodisponibilité supérieure de l'ingrédient actif.

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