C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2723431
The present invention relates to NIP thiazole derivatives of formula (I) as selective inhibitors of the enzyme 11--beta-hydroxysteroid dehydrogenase type 1(11-.beta.-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
La présente invention concerne des dérivés de thiazole NIP de formule (I) en tant qu'inhibiteurs sélectifs de l'enzyme 11-béta-hydroxystéroïde déhydrogénase de type 1 (11-ß-HSD-1). L'invention porte en outre sur l'utilisation de ces composés dans le traitement et la prévention du syndrome métabolique, du diabète, de la résistance à l'insuline, de l'obésité, des troubles lipidiques, du glaucome, de l'ostéoporose, des troubles cognitifs, de l'anxiété, de la dépression, des troubles immuns, de l'hypertension et d'autres maladies et états.
Carniato Denis
Charon Christine
Doare Liliane
Leriche Caroline
Roche Didier
Fetherstonhaugh & Co.
Merck Patent Gmbh
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