Nitrate esters and their use for mitigating cellular damage

Details Nitrate esters and their use for mitigating cellular damage Nitrate esters and their use for mitigating cellular damage

C - Chemistry, Metallurgy

07

D

C07D 495/10 (2006.01) A61K 31/095 (2006.01) A61K 31/21 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) C07C 321/14 (2006.01) C07C 323/03 (2006.01) C07C 323/09 (2006.01) C07D 209/44 (2006.01) C07D 277/30 (2006.01) C07D 307/82 (2006.01) C07D 311/16 (2006.01) C07D 311/66 (2006.01) C07D 333/42 (2006.01) C07D 339/04 (2006.01) C07D 339/08 (2006.01) C07D 409/12 (2006.01) C07D 417/06 (2006.01) C07D 487/04 (2006.01) C07D 491/052 (2006.01)

Patent

CA 2580627

Nitrate esters and methods for mitigating neurodegeneration, affecting neuroprotection, affecting cognition enhancement, and/or preventing or mitigating tissue and/or cellular damage in a subject are described. Neurological or cognitive conditions, or damage mediated by free radicals are treated by administering to a subject an effective amount of a therapeutic compound comprising a nitrate ester, or a pharmaceutically acceptable salt thereof.

L'invention concerne des esters de nitrate et des méthodes pour limiter la neurodégénérescence, influer sur la neuroprotection, sur l'amélioration cognitive et/ou prévenir ou limiter les dommages tissulaires et/ou cellulaires chez un sujet. Les états neurologiques ou cognitifs ou les dommages induits par des radicaux libres sont traités par administration à un sujet d'une quantité efficace d'un composé thérapeutique comprenant un ester de nitrate ou un de ses sels pharmaceutiquement acceptables.

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