Nitrate esters and their use for neurological conditions

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 339/08 (2006.01) A61K 31/04 (2006.01) A61K 31/21 (2006.01) A61K 31/255 (2006.01) A61K 31/26 (2006.01) A61K 31/275 (2006.01) A61K 31/341 (2006.01) A61K 31/381 (2006.01) A61K 31/385 (2006.01) A61K 31/39 (2006.01) A61K 31/426 (2006.01) A61K 31/506 (2006.01) A61K 31/575 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07C 203/04 (2006.01) C07C 255/14 (2006.01) C07C 317/18 (2006.01) C07C 319/00 (2006.01) C07C 323/12 (2006.01) C07C 331/10 (2006.01) C07C 381/02 (2006.01) C07D 277/24 (2006.01) C07D 307/33

Patent

CA 2364493

Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated by administering to a subject an effective amount of a therapeutic compound comprising a nitrate ester, or a pharmaceutically acceptable salt or ester thereof.

L'invention concerne des composés et des procédés destinés à réduire la neurodégénérescence et à assurer une protection neurologique et/ou une amélioration cognitive chez un sujet. On traite les états neurologiques ou cognitifs en administrant au sujet une quantité efficace d'un composé thérapeutique comprenant un ester de nitrate, ou son sel ou ester de qualité pharmaceutique.

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