Nitrate esters of piperidines

Details Nitrate esters of piperidines Nitrate esters of piperidines

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/445 (2006.01) A61K 31/538 (2006.01) A61P 9/00 (2006.01) C07D 211/42 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2660538

The application relates to novel nitrate ester derivatives of substituted piperidines of the general formula (I), wherein R1, R2, R3, X, Y and Z0, and m, n, p and q have the meanings explained in more detail in the description, a process for their preparation and the use of these compounds as a curative agent in cardiovascular diseases, in particular in high blood pressure and vascular and organ damage accompanying high blood pressure.

L'invention concerne de nouveaux dérivés de l'ester de nitrate de pipéridines substituées de formule générale (I), où R1, R2, R3, X, Y et Z0, et m, n, p et q ont les significations expliquées plus en détail dans la description, un procédé pour leur préparation et l'utilisation de ces composés comme agent curatif de maladies cardio-vasculaires, en particulier d'hypertension artérielle et de lésions vasculaires et d'organes qui accompagnent l'hypertension artérielle.

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