Nitric ester derivatives and their use in urinary...

A - Human Necessities – 61 – K

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A61K 31/63 (2006.01) A61K 31/21 (2006.01) A61K 31/215 (2006.01) A61K 31/216 (2006.01) A61K 31/245 (2006.01) A61K 31/33 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61P 13/00 (2006.01) C07C 203/04 (2006.01) C07C 211/46 (2006.01) C07C 229/58 (2006.01) C07C 311/00 (2006.01) C07C 311/08 (2006.01) C07D 209/08 (2006.01) C07D 209/28 (2006.01) C07D 209/48 (2006.01) C07D 209/72 (2006.01) C07D 213/00 (2006.01) C07D 213/74 (2006.01) C07D 231/12 (2

Patent

CA 2264081

Use of the following groups of compounds or their compositions for the preparation of medicaments for the treatment of urinary incontinence, such compounds having general formula: A-X1-NO2 or their salts, where A = R(COX)t and where t is an integer 0 or 1; X = O, NH, NR1C, where R1C is a linear or branched alkyl having from 1 to 10 C atoms; R is (IA) where t = 1 and X1 is equal to -YO- where Y is a C1-C20 alkylene, C5-C7 cycloalkyl or oxyalkyl derivatives.

L'invention concerne l'utilisation des groupes de composés ci-dessous ou de leurs compositions pour la préparation de médicaments pour traiter l'incontinence urinaire. Ces composés présentent généralement la formule A-X¿1?-NO¿2?. L'invention traite aussi de l'utilisation des sels de ces composés. Dans la formule, A = R(COX)¿t? et t est un nombre entier égal à 0 ou 1; X = O, NH, NR¿1C? où R¿1C? est un alkyle linéaire ou ramifié comportant 1 à 10 atomes; R est (IA) où t = 1 et X¿1? est égal à -YO- où Y est un alkylène C¿1?-C¿20?, cycloalkyle C¿5-?C¿7? ou des dérivés d'oxyalkyle.

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