Nitric oxide donor compounds

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 203/04 (2006.01) A61K 31/223 (2006.01) A61K 31/27 (2006.01) A61P 9/10 (2006.01) C07C 271/22 (2006.01)

Patent

CA 2677387

The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorders, immunological diseases, bone metabolism dysfunctions, central and peripheral nervous system diseases, sexual dysfunctions, infectious diseases, for the inhibition of platelet aggregation and platelet adhesion, for treating pathological conditions resulting from abnormal cell proliferation, vascular diseases. The invention also relates to compositions comprising at least one nitric oxide releasing compounds of the invention and composition comprising at least one nitric oxide releasing compounds according to the invention and at least one therapeutic agent.

La présente invention concerne des composés donneurs d'oxyde nitrique et leur utilisation pour traiter des maladies cardiovasculaires, les inflammations, la douleur, la fièvre, des troubles gastro-intestinaux, des maladies ophtalmiques, des troubles hépatiques, des maladies rénales, des troubles respiratoires, des maladies immunologiques, des dysfonctionnements du métabolisme osseux, des maladies du système nerveux central et périphérique, des dysfonctionnements sexuels, des maladies infectieuses, pour l'inhibition de l'agrégation plaquettaire et de l'adhésion plaquettaire, pour traiter des états pathologiques entraînés par la prolifération de cellules anormales, et les maladies vasculaires. La présente invention concerne également des compositions comprenant au moins un composé libérant de l'oxyde nitrique selon l'invention, et une composition comprenant au moins un composé libérant de l'oxyde nitrique selon l'invention et au moins un agent thérapeutique.

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