C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 291/04 (2006.01) A61K 31/13 (2006.01) A61K 31/131 (2006.01) A61K 31/785 (2006.01) C08F 8/30 (2006.01) C08G 73/02 (2006.01)
Patent
CA 2271013
The invention is directed to nitric oxide (NO) donor compounds (such as those of formulae 1-4) and to pharmaceutical compositions containing such nitric oxide (NO) donor compounds, for delivering NO to the apical surface of a mucosa, where the nitric oxide is released for passage across the epithelial monolayer of the mucous membrane. The NO donor compounds include polyalkyleneamine NO donors as well as tertiary and quaternary amino aliphatic NO donor compounds. The compounds and compositions of the invention are useful in any situation in which it is desirable to deliver NO across a mucosal surface. For example, the compounds and compositions of the invention are particularly useful in treating pulmonary hypertension, male impotence, and several other specific conditions.
L'invention a trait à des composés donneurs (comme ceux des formules 1-4) d'oxyde nitrique (NO) ainsi qu'à des compositions pharmaceutiques contenant ces composés servant à apporter de l'oxyde nitrique à la surface apicale d'une muqueuse, cet oxyde nitrique étant libéré pour traverser la monocouche épithéliale de la muqueuse. Les composés donneurs de NO comprennent des composés donneurs de NO polyalkylèneamine ainsi que des composés donneurs de NO amino-aliphatique tertiaire et quaternaire. Les composés et les compositions de l'invention se révèlent efficaces en toute situation où il est souhaitable de faire traverser la muqueuse par de l'oxyde nitrique. Ces composés et compositions se révèlent, notamment, des plus utiles pour traiter l'hypertension artérielle pulmonaire, l'impuissance masculine ainsi que plusieurs autres états pathologiques spécifiques.
Brilli Richard J.
Jacobs Brian
Roselle Dominick C.
Salzman Andrew L.
Smith Daniel J.
Brilli Richard J.
Children's Hospital & Medical Center
Jacobs Brian
Macrae & Co.
Roselle Dominick C.
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