A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/549 (2006.01) C07D 417/02 (2006.01)
Patent
CA 2597460
The invention describes novel compositions and kits comprising at least one nitric oxide enhancing diuretic compound, or pharmaceutically acceptable salts thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating conditions resulting from excessive water and/or electrolyte retention; (b) treating cardiovascular diseases; (c) treating renovascular diseases; (d) treating diabetes; (e) treating diseases resulting from oxidative stress; (f) treating endothelial dysfunctions; (g) treating diseases caused by endothelial dysfunctions; (h) treating cirrhosis; (j) treating pre- eclampsia; (k) treating osteoporosis; (1) treating nephropathy; (m) treating peripheral vascular diseases; (n) treating portal hypertension; (o) treating central nervous system disorders; (p) treating metabolic syndrome; (q) treating sexual dysfunctions; and (r) hyperlipidemia. The nitric oxide enhancing diuretic compounds comprise at least one nitric oxide enhancing group linked to the diuretic compound through one or more sites such as carbon, oxygen and/or nitrogen via a bond or moiety that cannot be hydrolyzed.
L'invention porte sur de nouvelles préparations et trousses comportant au moins un composé diurétique renforçateur d'oxyde nitrique ou ses sels préparations pharmaceutiques et facultativement au moins un composé diurétique renforçateur d'oxyde nitrique et/ou au moins un agent thérapeutique. L'invention porte en outre sur des méthodes de traitement: (a) d'états résultant d'une rétention excessive d'eau ou d'électrolyte; (b) de maladies cardio-vasculaires; (c) de maladies réno-vasculaires; (d) du diabète; (e) de maladies liées au stress oxydatif; (f) de dysfonctions endothéliales; (g) de maladies résultant de dysfonctions endothéliales; (h) de cirrhoses; (j) de pré-éclampsie; (k) de l'ostéoporose; l) des néphropathies; (m) de maladies vasculaires périphériques; (n) de l'hypertension portale; (o) de troubles du SNC; (p) du syndrome métabolique; (q) de dysfonctions sexuelles; et (r) de l'hyperlipémie. Lesdits composés diurétiques comprennent au moins un groupe renforçateur d'oxyde nitrique leur étant liés via un ou plusieurs sites telles que: carbone, oxygène et/ou azote par l'intermédiaire d'une liaison ou un d'un fragment non hydrolysable.
Earl Richard A.
Ezawa Maiko
Fang Xinqin
Garvey David S.
Gaston Ricky D.
Bennett Jones Llp
Nicox S.a.
Nitromed Inc.
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