Nitric oxide enhancing prostaglandin compounds, compositions...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 271/02 (2006.01) A61K 31/5575 (2006.01) A61K 31/559 (2006.01) C07C 405/00 (2006.01) C07D 273/00 (2006.01)

Patent

CA 2647859

The invention provides compositions and kits comprising at least one nitric oxide enhancing prostaglandin compound or a pharmaceutically acceptable salt thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating ophthalmic disorders; (b) treating cerebrovascular disorders; (c) treating cardiovascular disorders; (d) treating benign prostatic hyperplasia (BPH); (e) treating peptic ulcers; (e) treating sexual dysfunctions and (f) inducing abortions. The nitric oxide enhancing prostaglandin compounds comprise at least one heterocyclic nitric oxide donor group and/or at least one nitroxide group.

La présente invention concerne des compositions et des kits comprenant au moins une prostaglandine amplificatrice d'oxyde nitrique ou un sel de qualité pharmaceutique dudit composé, et, éventuellement, au moins un composé amplificateur d'oxyde nitrique et/ou au moins un agent thérapeutique. La présente invention concerne également des méthodes de (a) traitement des troubles ophtalmiques ; (b) traitement des troubles cérébrovasculaires ; (c) traitement des troubles cardio-vasculaires ; (d) traitement de l'hyperplasie bénigne de la prostate (HBP) ; (e) traitement des ulcères peptiques ; (e) traitement des troubles sexuels et (f) induction d'avortements. Les prostaglandines amplificatrices d'oxyde nitrique comprennent au moins un groupement donneur d'oxyde nitrique hétérocyclique et/ou au moins un groupement nitroxyde.

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