Nitric oxide in treatment of inflammation

Details Nitric oxide in treatment of inflammation Nitric oxide in treatment of inflammation

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/57 (2006.01) A61K 33/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2521052

Use of nitric oxide, in the form of gaseous nitric oxide or a nitric oxide donor, in combination with a glucocorticoid for the manufacture of a medicament for treating infectious inflammation in a mammal, including man, said combination being used in a therapeutically effective amount to accomplish treatment of said inflammation. Methods and a pharmaceutical composition for treatment of such an inflammation. Use of nitric oxide, in the form of gaseous nitric oxide or a nitric oxide donor, for the manufacture of a medicament for increasing the expression of glucocorticoid receptor in cells of a mammal, including man. A method for such an increase.

L'invention concerne l'utilisation d'oxyde nitrique, sous la forme d'oxyde nitrique gazeux ou d'un donneur d'oxyde nitrique, combiné à un glucocorticoïde pour la fabrication d'un médicament destiné au traitement d'une inflammation infectieuse chez un mammifère, y compris chez l'homme, ladite combinaison étant utilisée en une quantité thérapeutiquement efficace pour traiter ladite inflammation. L'invention concerne également des méthodes et une composition pharmaceutique destinées au traitement d'une telle inflammation. L'invention concerne l'utilisation d'oxyde nitrique, sous la forme d'oxyde nitrique gazeux ou d'un donneur d'oxyde nitrique, pour la fabrication d'un médicament destiné à augmenter l'expression d'un récepteur des glucocorticoïdes dans les cellules d'un mammifère, y compris chez l'homme. L'invention concerne un procédé permettant d'obtenir une telle augmentation.

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