C - Chemistry – Metallurgy – 08 – F
Patent
C - Chemistry, Metallurgy
08
F
C08F 8/30 (2006.01) A61K 31/78 (2006.01)
Patent
CA 2581939
The invention described herein provides for novel nitric oxide-releasing polymers that comprise at least two adjacent units derived from acrylonitrile monomer units and containing at least one carbon-bound diazeniumdiolate. The diazeniumdiolated acrylonitrile-derived polymers can be used in medical devices therapeutically. Accordingly, the invention also provides a method of treating a biological disorder and a method of promoting angiogenesis that includes administering a medical device comprising a nitric oxide-releasing polymer comprising at least two adjacent units of acrylonitrile before exposure to nitric oxide and at least one nitric oxide releasing N2O2- group, wherein the N2O2- group is attached directly to the polyacrylonitrile backbone, to a specific location on or within the mammal in an amount effective to treat the biological disorder or promote angiogenesis.
L'invention concerne de nouveaux polymères libérant du monoxyde d'azote qui comprennent au moins deux unités adjacentes dérivées d'unités de monomères à base d'acrylonitrile et contenant au moins un diazéniumdiolate lié au carbone. Les polymères diazéniumdiolatés dérivés d'acrylonitrile peuvent être utilisés dans des dispositifs médicaux à des fins thérapeutiques. Par conséquent, l'invention concerne également une méthode de traitement d'un trouble biologique et une méthode de stimulation de l'angiogenèse qui consiste à administrer un dispositif médical comprenant un polymère libérant du monoxyde d'azote comprenant au moins deux unités adjacentes d'acrylonitrile avant une exposition au monoxyde d'azote et au moins un groupe N2O2- libérant du monoxyde d'azote, le groupe N2O2- étant directement lié au squelette du polyacrylonitrile, à un endroit spécifique situé sur ou dans un mammifère, en quantité efficace pour traiter le trouble biologique ou stimuler l'angiogenèse.
Citro Michael L.
Derosa Frank
Hrabie Joseph A.
Keefer Larry K.
Department Of Health And Human Services Government Of The United States Of America Represented By The Se
Ridout & Maybee Llp
LandOfFree
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