Nitric oxide-releasing dressings

A - Human Necessities – 61 – L

Patent

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Details

A61L 15/46 (2006.01) A43B 7/00 (2006.01) A43B 13/38 (2006.01) A61K 33/00 (2006.01) A61L 15/18 (2006.01) A61P 31/02 (2006.01)

Patent

CA 2740135

The invention relates to the use of nitric-oxide-releasing anti-septic agents in wound dressings. The dressing may comprise a bottom layer that is permeable to gaseous NO and an upper surface barrier that is relatively gas and moisture-impermeable to prevent premature dispersion of the gas. The dressings comprise a plurality of layers, one layer comprising a supply of sodium nitrite and citric acid, and another layer comprising a supply of water contained within capsules and/or frangible packets. Release of NO occurs when sodium nitrite and citric acid come into contact with the water supply. This activation is performed either by applying pressure on the dressing which will result in the breakage of the capsules and/or packets or through a pull-tab attached to such capsules and/or packets. The dressings may further comprise an oxygen- releasing component.

L'invention porte sur l'utilisation d'agents antiseptiques libérant de l'oxyde nitrique dans des pansements de blessure. Le pansement peut comprendre une couche inférieure qui est perméable au NO gazeux et une barrière de surface supérieure qui est relativement imperméable aux gaz et à l'humidité afin d'empêcher une dispersion prématurée du gaz. Les pansements comprennent une pluralité de couches, une couche comprenant une alimentation en nitrure de sodium et en acide citrique, et une autre couche comprenant une alimentation en eau contenue à l'intérieur de capsules et/ou de paquets cassants. La libération de NO se produit lorsque le nitrure de sodium et l'acide nitrique viennent en contact avec l'alimentation en eau. Cette activation est exécutée soit par application d'une pression sur le pansement qui amènera à la rupture des capsules et/ou des paquets, soit au moyen d'une tirette fixée à de telles capsules et/ou paquets. Les pansements peuvent en outre comprendre un composant libérant de l'oxygène.

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