Nitric oxide-releasing molecules

Details Nitric oxide-releasing molecules Nitric oxide-releasing molecules

C - Chemistry, Metallurgy

07

C

C07C 245/04 (2006.01) A61K 31/655 (2006.01)

Patent

CA 2555552

This invention relates to compositions comprising carbon-based diazeniumdiolates that release nitric oxide (NO). The carbon-based diazeniumdiolated molecules release NO spontaneously under physiological conditions without subsequent nitrosamine formation. The present invention also relates to methods of preparing the carbon-based diazeniumdiolated molecules, compositions comprising such molecules, methods of using such compositions, and devices employing such molecule compositions.

Cette invention concerne des compositions renfermant des diazéniumdiolates à base de carbone qui libèrent du monoxyde d'azote (NO). Les molécules diazéniumdiolatées à base de carbone libèrent du monoxyde d'azote spontanément dans certaines conditions physiologiques sans formation subséquente de nitrosamine. Cette invention concerne également des procédés de préparation de ces molécules diazéniumdiolatées à base de carbone, des compositions renfermant ces molécules, des procédés d'utilisation de ces compositions et des dispositifs utilisant ces compositions de molécules.

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